In standard diffusion-weighted imaging, the parameter maps are calculated based on a set of magnitude images. The standard fitting model of the parameter maps does not take a noise-induced bias into account. A noise offset model for Intravoxel Incoherent Motion (IVIM) in Diffusion Weighted Imaging (DWI) is introduced and the impact on diffusion parameter maps is evaluated for muscle and synovia of the knee joint. Parameter fitting using the noise-offset model results in faster signal decay of the fitted curve and therefore in increased diffusion coefficients compared to standard IVIM mapping.
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