We investigated the diffusion fiber response function by characterizing the modelled diffusivity, the shape, and the size of the diffusion signal in regions of single fiber populations. We show that the various descriptors of the diffusion signal vary significantly across white matter pathways within a subject, and across subjects for a given pathway. Analysis of variance suggests that variability between pathways is greater than across subjects. Understanding the response function and its variation are necessary for accurate fiber orientation characterization, as well as characterizing microstructural effects from geometrical effects within a voxel.
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