We report the acquisition of whole brain, 2-mm isotropic resolution DDE data in a healthy volunteer using an orientationally invariant sampling scheme and quantify the mean DDE signal intensity across cortical regions as a measure of diffusion restriction within different cortices. Higher mean signal intensities were observed in the cerebellum and limbic cortices, which are thought to reflect a higher degree of restriction in the tissue microstructural environment and may correspond to densely packed, small granule and pyramidal cells known to be present in these regions.
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