Abstract #4309

Investigating the effect of diffusion MRI acquisition parameters on free water signal fraction estimates from 3-tissue CSD techniques

Benjamin T Newman^1,2, Thijs Dhollander^3,4, and T. Jason Druzgal^1,2

¹Department of Radiology & Medical Imaging, Division of Neuroradiology, University of Virginia Health System, University of Virginia, Charlottesville, VA, United States, ²Brain Institute, University of Virginia, Charlottesville, VA, United States, ³The Florey Department of Neuroscience, University of Melbourne, Melbourne, Australia, ⁴The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia

The CSF-like free water signal fraction is an advanced diffusion MRI metric representing the freely diffusing water in brain tissue. Different methods to calculate the free water signal fraction using constrained spherical deconvolution exist but it is still unknown how variation in data quality and acquisition affect measurements. Using a large clinical dataset with highly variable acquisition schemes, this study shows that the various acquisition parameters significantly affect outcome free water signal fraction, though the multi-shell analysis method is more susceptible than the single-shell method. This highlights the importance of harmonization and quality clinical imaging.

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