Abstract #4299

Rapid DTI-based free water elimination and mapping with explicit T2 modelling using a dual-echo Stejskal-Tanner EPI sequence

Ezequiel Farrher¹, Richard P. Buschbeck¹, Kuan-Hung Cho², Ming-Jye Chen², Seong Dae Yun¹, Zaheer Abbas¹, Chang-Hoon Choi¹, Li-Wei Kuo^2,3, and N. Jon Shah^1,4,5,6

¹Institute of Neuroscience and Medicine 4, Forschungszentrum Jülich, Jülich, Germany, ²Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, Taiwan, ³Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, ⁴Department of Neurology, RWTH Aachen University, Aachen, Germany, ⁵JARA - BRAIN - Translational Medicine, Aachen, Germany, ⁶Institute of Neuroscience and Medicine 11, JARA, Forschungszentrum Jülich, Jülich, Germany

We propose and investigate a dual-echo (DE) Stejskal-Tanner EPI sequence for rapid DTI-based free water elimination and mapping with explicit T₂ modelling (FWET₂) in vivo. DTI maps from the DE sequence are artefact-free and similar to the standard, individual echo (IE) approach. Compared to the IE case, an underestimation of T₂ values calculated from the DE sequence is observed. The T₂ underestimation stems from reduced signal amplitudes in the second echo of the DE sequence, which we demonstrate to correlate with imperfect refocusing RF pulses. A simple correction method is proposed. FWET₂ model parameters derived from both sequences are comparable.

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