Abstract #4162

In vivo MRI measurement of microstructural constraints for direct drug delivery within the brain

Antonella Castellano¹, Alice Segato², Valentina Pieri¹, Marco Vidotto², Nicolò Pecco¹, Marco Riva^3,4, Riccardo Secoli⁵, Davide Danilo Zani⁶, Stefano Brizzola⁶, Marco Trovatelli⁷, Giuliano Ravasio⁶, Marcello Cadioli⁸, Lorenzo Bello^4,9, Ferdinando Rodriguez Y Baena⁵, Elena De Momi², and Andrea Falini¹

¹Neuroradiology Unit and CERMAC, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy, ²Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy, ³Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan, Italy, ⁴Neurosurgical Oncology Unit, IRCCS Humanitas Clinical and Research Center, Rozzano (MI), Italy, ⁵Department of Mechanical Engineering, Imperial College London, London, United Kingdom, ⁶Department of Veterinary Medicine, Università degli Studi di Milano, Milan, Italy, ⁷Department of Health, Animal Science and Food Safety, Faculty of Veterinary Medicine, Università degli Studi di Milano, Milan, Italy, ⁸Philips Healthcare, Milan, Italy, ⁹Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy

Brain tissue microstructure may influence the efficient delivery of therapeutics within the brain. Diffusion Tensor Imaging (DTI) enables the depiction of tissue properties in vivo, and thus is potentially relevant for planning convection-enhanced delivery (CED) within the brain. We report on the quantitative assessment of the distribution of a Gadolinium solution infused by CED within the brain of a live ovine model. Infusate distributions were measured at multiple timepoints and compared to microstructural properties as depicted by DTI, thus demonstrating the impact of tissue features and catheter positioning on drug distribution in vivo.

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