Abstract #4147

Development of a first principles-based model of brain thermoregulation and initial validation with MR chemical shift thermometry

Dongsuk Sung¹, Peter A. Kottke², Jason W. Allen^3,4, Fadi Nahab⁴, Andrei G. Fedorov^2,5, and Candace C. Fleischer^1,3,5

¹Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States, ²Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, United States, ³Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, ⁴Department of Neurology, Emory University School of Medicine, Atlanta, GA, United States, ⁵Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, United States

Brain temperature regulation is a key parameter after injury and ischemia. Experimental magnetic resonance (MR)-based thermometry is promising but not always clinically feasible. To complement MR thermometry measures, an improved thermal model of the brain based on first principles has been developed that rigorously ensures energy conservation in thermally interacting brain domains. As initial validation, a temperature map was generated using our model with MR angiography (MRA) and structural MR imaging (MRI) data, and compared with experimental chemical shift thermometry (CST) in the same subject. Biophysical models provide further insight into brain thermoregulation by complementing experimental thermometry measurements.

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