Abstract #4138

Multi-Radiofrequency Thermal Magnetic Resonance Targeting Glioblastoma Multiforme

Eva Oberacker¹, Andre Kuehne², Thomas Wilhelm Eigentler¹, Cecilia Diesch¹, Jacek Nadobny³, Pirus Ghadjar³, Peter Wust³, and Thoralf Niendorf^1,2,4

¹Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, ²MRI.TOOLS GmbH, Berlin, Germany, ³Clinic for Radiation Oncology, Charité Universitätsmedizin, Berlin, Germany, ⁴Experimental and Clinical Research Center (ECRC), joint cooperation between the Charité Medical Faculty and the Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

Ultrahigh field (UHF) MR employs higher radio frequencies (RF) than conventional MR and has unique potential to provide focal temperature manipulation and high resolution imaging (ThermalMR), as our simulations and experimental work demonstrated for f=300MHz. Here we use EMF simulations to demonstrate the added value for multi-frequency thermal intervention (f=300MHz-500MHz) to boost the efficacy of the heating paradigm for clinical target volumes (TVs) of two brain tumor patients. An optimization algorithm was developed to study RF power deposition in the TV for a single, double or triple frequency set permitting highest RF power deposition in the TV.

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