Abstract #4133

Real-Time Temperature Monitoring during MR Imaging Guided Photothermal Therapy

Boyu Zhang¹, Xianfu Meng², Yuwen Zhang¹, Wenbo Bu², and He Wang^1,3

¹Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, ²School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China, ³Human Phenome Institute, Fudan University, Shanghai, China

It is a challenge that accurate monitoring the spatial distribution of photothermal transducing agents (PTAs), meanwhile, real-time mapping temperature in photothermal therapy. Here, we propose an effective strategy that integrates T1 and MR temperature imaging for tracking nanoPTAs and real-time temperature monitoring in vivo. The synthesized nanoPTAs equip with favorable T1 performance and marginal susceptibility guaranteeing the accuracy of temperature mapping. The time resolution is 20 seconds, and the detection accuracy of temperature change is as low as 0.1K, which contributes to promoting the clinical application of photothermal therapy.

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