Abstract #4117

Monitoring of Focused Ultrasound Induced Stable Cavitation by Using Magnetic Resonance Imaging: In Vivo Experiments

Yu-Ting Jiang¹, Cheng-Tao Ho¹, Po-Hung Hsu², Hao-Li Liu³, Chih-Kuang Yeh¹, and Hsu-Hsia Peng¹

¹Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, ²Center for Advanced Molecular Imaging and Translation, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ³Department of Electrical Engineering, Chang-gung University, Taoyuan, Taiwan

We aimed to monitor the focused ultrasound (FUS)-induced stable cavitation (SC) by using single-shot turbo spin-echo based sequence in in vivo experiments. The FUS were transmitted to the cortex ~2‐mm beneath the superior sagittal sinus of rats with acoustic pressure=0.5 or 0.8 MPa. A cavitation index map was computed to highlight the occurrence of SC at focus. In conclusion, the simultaneous acquisitions of spin-echo based images during FUS transmission and the proposed CI map can immediately localize the position occurring SC. The relevant information can be feedbacked to FUS facility for improving the procedure of BBB opening.

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