Magnetic Resonance guided High Intensity Focused Ultrasound (MRgHIFU) is accepted for the non-invasive ablation of localized tumors. Thermal contrast between the target tissue and pre/post focal tissues can be improved for highly perfused tumors by injection of liquid core micro-droplets, used as endovascular sono-sensitizers. We are aiming to provide a substitution model for living organs or perfused ex vivo organs to facilitate the investigation of new sono-sensitizers and sonication paradigms. We are reporting an experimental model that is suitable for MR-guided HIFU studies, offering in situ tunable perfusion rate, multi-compartment structure, and tunable concentration of sono-sensitizers and dissolved gases.
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