This study explored the temporal variability of functional connectivity among the brain networks in obsessive-compulsive disorder (OCD) patients. First, dynamic analysis suggested four distinct connectivity states. Relative to controls, OCD patients showed more frequent and larger-scale within and between-network connectivity changes at state II, whereas less frequent and smaller-scale between-network connectivity alterations appeared at state I and IV. Second, this study suggested a new network dysconnectivity model between SMN, DMN, cerebellum and visual network for OCD patients. These findings demonstrated the dynamic changes of brain network connectivity patterns in OCD, providing a new insight into OCD-related brain functional network alterations.
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