Schizophrenia is a severe psychiatric condition, and is hypothesized to result from abnormal anatomical neural connectivity and a consequent decoupling of the brain’s integrative thought processes. Here we analysed and compared resting state functional magnetic resonance imaging (rs-fMRI) data from forty-four schizophrenia patients (SZ) and forty healthy subjects (HS). Complex network analysis of brain functional connectivity revealed that SZ networks are characterized by more stable configurations with a lower level of flexibility of functional plasticity than HS networks, which may depend on an abnormal synaptic connectivity due to a dysfunctional cortical pruning.
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