Abstract #3978

Decreases in functional connectivity of white matter in a resting state and during a working memory task in schizophrenia

Yurui Gao^1,2, Muwei Li^1,3, Anna S Huang⁴, Adam W Anderson^1,2,3, Zhaohua Ding^1,5, Stephan H Heckers^3,4, Neil D Woodward⁴, and John C Gore^1,2,3

¹Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ²Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ³Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ⁴Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ⁵Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States

White matter (WM) pathological changes play a role in disturbing neural connectivity of schizophrenic subjects. We extended our previous analyses of WM-GM connectivity to quantify WM functional differences during a resting state and a working memory task between schizophrenic patients and healthy controls. Significant deficits of functional connectivity were found in several WM tracts in schizophrenic patients relative to healthy controls. These findings add further evidence of the presence of WM changes in schizophrenia subjects compared to controls and further illustrate the potential relevance of functional signals arising from WM in a task and at rest.

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