Temporal lobe epilepsy (TLE) is a disorder of altered brain networks. We evaluated the functional connectivity of the brain limbic system believed to be affected by TLE, based on resting state functional MRI and the graph network analysis. Our results showed that insula, posterior cingulate gyrus, and thalamus may undergo abnormal functional connectivity in terms of local degree in both right and left TLE compared to the healthy subjects. Furthermore, our results suggest that functional connectivity, as evaluated by local degree in insula and thalamus may have a potential application to help determine the laterality in cases of TLE.
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