Abstract #3951

Role of the combination of T2 values and edema volume as a biomarker in evaluating the neuroprotective effect of LITUS to moderate TBI with rat model

Du Juan¹, Zheng Tao¹, Yuan Yi², Wang Zhanqiu¹, Liu Defeng¹, Shi Qinglei³, Wu Shuo¹, Wang Xiaohan¹, and Liu Lanxiang¹

¹MRI, Qinhuangdao Municipal No. 1 Hospital, Qinhuangdao, China, ²Institute of Electrical Engineering, Yanshan University, Qinhuangdao, China, ³Siemens Healthcare, MR Scientific Marketing, Beijing, China

In this study, we verified the feasibility of T2 values combined with edema volume changes in evaluating the neuro therapeutic effect of low-intensity transcranial ultrasound stimulation (LITUS) on post-traumatic brain edema with rat model. The neuro therapeutic effect of LITUS was attributed to inhibiting the expression of AQP4 and promoting the removal of β-APP.

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