Abstract #3922

Mapping the brain-wide network effects by optogenetic activation of the corpus callosum with an MRI-guided robotic arm

Yi Chen^1,2, Filip Sobczak^1,2, Patricia Roldán Pais^1,2, Cornelius Schwarz³, Alan P. Koretsky⁴, and Xin Yu^1,5

¹Research Group of Translational Neuroimaging and Neural Control, High-field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, ²Graduate School of Neural Information Processing, University of Tübingen, Tübingen, Germany, ³Werner Reichardt Center for Integrative Neuroscience, Tübingen, Germany, ⁴Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, ⁵Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States

This study not only specifies the optogenetically driven corpus callosum-mediated regulation of the local excitation/inhibition balance in the local barrel cortex, but also depicts the power of the multi-modal fMRI to characterize the brain-wide network activity associated with circuit-specific optogenetic activations. It highlights a vital aspect of the brain-wide activation for circuit-specific causality studies with optogenetic tools.

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