Systemic inflammation and immune dysregulation have been considered as risk factors in the pathophysiology of mood disorders including bipolar disorder (BD). Previous metabolism, structural and functional neuroimaging studies have reported the specific regional brain volumetric alteration and dysfunction of the insula in BD. Taken together, in current study, the associations between the whole-brain dFC of each insular subdivision in unmedicated patients with BD and the level of pro-inflammatory cytokines were analyzed. Our results demonstrated that the clinical risk factors might relate to the aberrant dFC in specific insular subdivision.
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