Abstract #3908

Hemodialysis is associated with more severe disrupted brain functional networks in patients with end-stage renal disease

Baolin Wu¹, Lei Li¹, Zhiyun Jia^1,2, and Qiyong Gong^1,3

¹Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, ²Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, China, ³Department of Psychology, School of Public Administration, Sichuan University, Chengdu, China

Although patients with end-stage renal disease (ESRD) have shown brain structural and functional alterations, the change patterns of the whole-brain functional networks remain largely unknown. We aimed to explore the brain functional topologic organization differences among ESRD patients with hemodialysis (HD) and without dialysis and healthy controls (HCs) using graph-based network analysis. Compared with HCs, ESRD patients showed aberrant global and local topologic organizations, which is more obvious in HD patients. Furthermore, some topologic parameters were associated with cognitive performances and clinical markers.

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