We found a negative correlation between brain activity estimates of two conditions, daily recognition and trauma memory remembering, that reflected altered responses in PTSD. We conducted two task-fMRI runs for 9 patients with PTSD and the matched controls employing a script-driven imagery task. A region-of-interest analysis revealed a negative correlation between a hyperarousal subscale of psychological assessment and the activity estimate in the hippocampus in the daily recognition whereas a positive correlation in the trauma memory remembering. When computing voxel-based correlations between the activity estimates of the two conditions, extensive negative correlations emerged around the hippocampus in patients.
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