A multiband (MB) multi-echo (ME) pseudocontinuous arterial spin labeling (pCASL) sequence has shown improved cerebrovascular reactivity (CVR) calculations compared to a single echo; however, pCASL significantly increases TR. This study compared a MBME pCASL sequence to MBME and MB single echo acquisitions for the calculation of CVR. TSNR was higher for the MBME pCASL sequence compared to the MBME and MBMS sequences, and mean CVR was comparable between all sequences. The ME sequences had improved quality in areas with high susceptibility. Despite significantly longer TR, the MBME pCASL sequence performed comparably to the MBME sequence, while simultaneously providing ASL data.
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