Abstract #3838

Characteristics of temporal dynamics of intrinsic brain activity in unmedicated bipolar II disorder with suicidality

JiaYing Gong^1,2, Guanmao Chen¹, Yanbin Jia³, Long Qian⁴, Li Huang¹, and Ying Wang¹

¹Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China, ²Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ³Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou, China, ⁴MR Research, GE Healthcare, Beijing, China

The alterations of brain dynamics in bipolar disorder (BD) with suicidality are still unknown. Dynamic amplitude of low-frequency fluctuations (dALFF) was evaluated using sliding window analysis, and the severity of suicidality was predicted using a multivariate regression model between 106 BD II participants. Our findings suggest that alterations of temporal variability in the precuneus/ posterior cingulate cortex (PCC) is a common feature of BD participants, the right temporal lobe involved in impulsivity, social and emotional processing are associated with suicidality in BD II depression

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