We evaluated the effects of a reference image and keyhole factor selections for high-frequency substitution on a keyhole imaging technique for application in glutamate CEST (GluCEST) imaging to reduce data acquisition time. The calculated GluCEST signals and visually inspected results from the reconstructed GluCEST maps indicated that a combination of unsaturated image as a reference image and >50% of keyhole factors showed consistent signals and image quality as opposed to the fully-sampled CEST data. Combining the keyhole imaging technique with GluCEST imaging enables stable image reconstruction and quantitative evaluation, and this approach is potentially implemented in various CEST imaging applications.
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