Abstract #3790

Acceleration of 3D high-resolution variable-flip-angle T1 mapping based on SUPER

Fan Yang¹, Jun Xie², Guobin Li², Meng Jiang³, and Chenxi Hu⁴

¹College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China, ²United Imaging Healthcare Co., Ltd, Shanghai, China, ³Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, ⁴Institute of Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China

Three-dimensional variable-flip-angle(VFA) T1-mapping is a rapid T1 quantification method with important clinical applications. However, the requirement of acquiring multiple 3D images greatly increases the scan time. We propose a novel application of SUPER—a recently developed framework for parametric mapping acceleration—to reduce scan time and/or improve spatial resolution of 3D VFA T1-mapping. In healthy subjects, we demonstrate that SUPER(R=2) and SUPER-SENSE(R=4 combining SUPER and parallel imaging) achieved similar accuracy, reasonable noise amplification, and similar reconstruction time compared with the non-acceleration gold standard. The whole upper-brain T1-mapping scan time was reduced from 5.33 minutes to 1.33 by employment of SUPER-SENSE.

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