Accurate, high-spatial resolution whole-brain pharmacokinetic maps are highly desirable in clinical neuro-oncology practice. A new dual-temporal resolution based kinetic mapping technique for this purpose, termed LEGATOS, was recently described and tested with in-vivo patient data. In this study, quantitative assessment of the accuracy of parameter estimates derived using the LEGATOS analysis procedure was evaluated through computer simulation. Structural similarity and percentage deviation of the “measured” values from the known “true” values were used for evaluation and demonstrated that the LEGATOS technique offered superior accuracy compared to the use of unreconstructed composite HT and HS curves alone.
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