Abstract #3757

Validity and reproducibility of Magnetic Resonance Fingerprinting in the healthy human brain at 3T

Joely Smith^1,2, Ben Statton³, Sarah Cardona¹, Mary Elizabeth Finnegan^1,2, Rebecca Abigail Quest^1,2, and Matthew Grech-Sollars^1,4

¹Department of Imaging, Imperial College Healthcare NHS Trust, London, United Kingdom, ²Department of Bioengineering, Imperial College London, London, United Kingdom, ³MRC London Institute of Medical Sciences, Imperial College London, London, United Kingdom, ⁴Department of Surgery and Cancer, Imperial College London, London, United Kingdom

Obtaining quantitative measurements in a 7-minute acquisition could improve the sensitivity of MR diagnosis. We investigated the validity and reproducibility of magnetic resonance fingerprinting (MRF) relaxometry in 12 tissue compartments in the human brain through comparison to standard mapping techniques: variable flip angle for T1 and multi-echo spin echo for T2. Statistically significant strong and moderate correlations were found between the MRF and standard mapping methods for T1 and T2, respectively. The MRF results were shown to be highly reproducible and in agreement with values found within the literature. However, a bias was found between MRF and standard relaxometry methods.

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