FRONSAC has previously been demonstrated as a highly effective approach to using nonlinear gradients to reduce undersampling artifacts, but previous results were limited to proof-of-principle experiments in individual subjects. Here we report quantitative comparisons for a full protocol of standard brain imaging sequences (2D GRE, 2D TSE, 2D T2w-FLAIR, 3D GRE and 3D MP-RAGE) acquired in a cohort of healthy subjects, comparing standard Cartesian to FRONSAC-enhanced acquisitions. Preliminary results confirm that FRONSAC significantly improves undersampling artifacts, measured as RMSE relative to a fully sampled Cartesian reference, while retaining the contrast, SNR, and reliability of standard Cartesian sequences.
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