MOCCO reconstruction enables high spatial and temporal resolution DCE imaging for breast, which was proposed to be less sensitive to modeling error. However, the impact of noise level and lesion size on reconstruction performance is remained unknown. In this work we use a digital reference object phantom with the ability to adjust both spatial and temporal features for breast pharmacokinetic simulation. Further, we perform G-factor analysis of SNR performance, sharpness assessment, nRMSE and PK analysis for evaluating the temporal fidelity.
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