Abstract #3445

A rapid quantitative Multi-inversion SAGE-EPI brain protocol with subspace reconstruction and navigation-free shot-to-shot phase correction

Mary Kate Manhard^1,2, Zijing Dong^1,3, Congyu Liao^1,2, Merlin Fair^1,2, Fuyixue Wang^1,4, Berkin Bilgic^1,2, and Kawin Setsompop^1,2,4

¹A.A. Martinos Center for Biomedical Imaging, Boston, MA, United States, ²Department of Radiology, Harvard Medical School, Boston, MA, United States, ³Department of Electrical Engineering and Computer Science, Massachusetts Institution of Technology, Cambridge, MA, United States, ⁴Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, United States

Recently, multi-contrast EPI approaches have been proposed for a fast screening brain protocol. With EPI-encoding, multiple contrasts can be acquired quickly for robust, quantitative mapping as well as creation of synthetic weighted images. Here, a spatiotemporal subspace reconstruction is developed to jointly reconstruct multi-contrast multishot-EPI data from a multi-inversion Spin and Gradient echo EPI (MI-SAGE-EPI) acquisition. An approach to estimate and incorporate shot-to-shot phase corruption into the reconstruction was also developed. This navigation-free subspace reconstruction achieves good reconstruction for MI-SAGE-EPI at a high EPI-acceleration, thus enabling a rapid quantitative protocol at high in-plane resolution with minimal distortion and blurring.

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