Abstract #3281

Variable Density Sampling of 3D TSE Cartesian Acquisition for Improved Robustness and SNR of ASL-MRI

Yiming Wang¹, Limin Zhou¹, Joshua S. Greer^1,2, Marco C. Pinho^1,3, Joseph A. Maldjian^1,3, and Ananth J. Madhuranthakam^1,3

¹Radiology, UT Southwestern Medical Center, Dallas, TX, United States, ²Pediatrics, UT Southwestern Medical Center, Dallas, TX, United States, ³Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States

3D Cartesian turbo spin echo (TSE) acquisition has shown robustness for arterial spin labeled (ASL) MRI. However, 3D Cartesian TSE are acquired with single average due to relatively long TR and longer scan times, which may lead to suboptimal signal to noise ratio (SNR). In this study, we implemented variable density sampling of 3D Cartesian TSE that acquires the center of the k-space with higher signal averages, and improves the robustness and SNR without significantly prolonging the scan time. We further combined this with M₀ images using partial k-space to compensate for increased scan time, but without compromising perfusion quantification.

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