Saturation pulses are an indispensable part in Chemical Exchange Saturation Transfer (CEST) imaging. Different saturation schemes can be designed for CEST imaging, including the pulse shape, duration of each pulse element, number of pulse elements, inter-pulse spoiler gradient, and inter-pulse gap, etc. Here, the impact of saturation schemes subject to practical B0 inhomogeneity is investigated, using Bloch simulations, and phantom and human experiments. Specifically, it’s shown that Gaussian and rectangular saturation pulses demonstrate substantially different susceptibility to imaging artifacts in the presence of B0 inhomogeneity when changing the duration of each saturation pulse element, and the inter-pulse spoiler gradients.
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