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Abstract #3168

Quantitative Estimation of Visual Sensitivity to Early Pathological Changes in T­2-Weighted Images

Chen Solomon1, Tamar Blumenfeld-Katzir1, Moti Salti2,3, Dvir Radunsky1, Noam Omer1, Neta Stern1, and Noam Ben-Eliezer1,4,5
1Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel, 2Brain Imaging Research Center (BIRC), Soroka Medical Center, Beer Sheva, Israel, 3Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer Sheva, Israel, 4Center for Advanced Imaging Innovation and Research (CAI2R), New-York University Langone Medical Center, New York, New York, NY, United States, 5Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv, Israel

Quantitative MRI (qMRI) may provide higher sensitivity to early pathological changes than standard qualitative assessment. This advantage, however, is yet to be rigorously compared with conventional diagnostic methods. This study aims to quantify the human ability to detect predefined changes in T2-weighted images as part of the diagnostic process of multiple sclerosis (MS). A visual diagnostic test was performed on neurosciences students, suggesting that the human vision has lower sensitivity to subtle MS lesions in T2-weighted images, in comparison to quantitative assessment of the change in T2 values.

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