Abstract #3166

Quality assurance of multiparametric mri protocol for multi-centre prostate cancer sequential imaging clinical trial

Yu-Feng Wang^1,2, Gary Liney^2,3, Robba Rai^2,3, Sirisha Tadimalla¹, Jonathan Goodwin⁴, Lois Holloway^2,3, and Annette Haworth¹

¹Institute of Medical Physics, The University of Sydney, Camperdown, Australia, ²Ingham Institute for Applied Medical Research, Liverpool, Australia, ³Liverpool and Macarthur Cancer Therapy Centre, Liverpool Hospital, Liverpool, Australia, ⁴Radiation Oncology Department, Calvary Mater Newcastle, Newcastle, Australia

Inter-/intra-scanner differences contribute to uncertainties in results from multi-centre longitudinal imaging studies. The Sequential Imaging Biofocussed Radiotherapy (SI-BiRT) trial is a multi-centre longitudinal imaging clinical trial that aims to develop imaging biomarkers using mpMRI to predict radiation therapy response in prostate cancer. Here we quantify the inter-/intra-scanner variabilities in the mpMRI protocol and scanners used in the SI-BiRT trial using commercial phantoms. ADC measurements were highly accurate while VFA T1 mapping overestimated reference values. ADC and T1 showed high intra-scanner reproducibility while R2* showed higher variability. The quantified uncertainties will be considered when interpreting results from the SI-BiRT trial.

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