The response to radiation treatment of DU145 prostate tumour xenografts was studied by comparing magnetization transfer-weighted Z-spectra before and after treatment. ROIs were drawn in homogenous sections of the tumour and analyzed based on corresponding TUNEL histology images. MTR decreased more than 1 week post-treatment in tumours that responded to treatment but was unchanged for non-responding tumours. The technique introduced in this study could potentially introduce a non-invasive way of determining treatment efficacy based on tumour necrosis/apoptosis.
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