Compared to conventional dynamic contrast-enhanced MR-mammography, which is known to be significantly affected by the phase of the menstrual cycle, the menstrual cycle-related effect on APT CEST MRI in the human breast is still unknown. This is the first study investigating the influence of the menstrual cycle on APT CEST MRI in fibroglandular breast tissue of seven healthy premenopausal women. No significant signal intensity differences in fibroglandular breast tissue between the follicular and the luteal phase of the menstrual cycle were observed, which suggests that APT contrasts are comparable regardless of the phase of the menstrual cycle in premenopausal women.
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