Abstract #3081

Detection of Superparamagnetic Iron Oxide Nanoparticles using Statistical Analysis of a Block Design Modulated bSSFP (BDM-bSSFP) Acquisition

Eugene Milshteyn^1,2, Bastien Guerin^1,2, and Lawrence L. Wald^1,2,3

¹Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, United States

The current standard methods for magnetic resonance imaging of superparamagnetic iron oxide nanoparticles (SPIONs) can be subject to “1/f” physiological fluctuations that can confound pre/post comparisons. We present a method to combine Block Design contrast Modulations and statistical analysis with the bSSFP sequence (BDM-bSSFP) in order to mitigate this effect. To do this, we leverage the frequency response of the bSSFP sequence to the local fields created by SPIONs. We show the ability of this method to detect SPIONs down to 10 μg/mL through simulations and in-vitro acquisitions.

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