Simultaneous PET/MRI offers a unique opportunity to investigate the relationship between concurrent phenomena measured by MET-PET and PWI-MR at the same physiological condition. Although 11C-Methionine uptake and perfusion are tightly coupled, it is not clear whether tumor regions (VOIs) defined by PWI and MET are overlapped and how the values of the corresponding parametric maps are distributed within each VOI. This preliminary work aims at studying the spatial relationship between PWI-MRI maps and MET-PET in brain tumors using a fully integrated PET/MRI system.
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