Wenhui Huang1,2, Kun Wang2, Jie Tian2, and Shuixing Zhang1
1the First Affiliated Hospital,Jinan University, Guangdong, China, 2Institute of Automation, Chinese Academy of Sciences, Beijing, China
The accurate imaging hypoxia is especially vital for nasopharyngeal carcinoma (NPC) patients undergoing radiotherapy. Multimodality molecular imaging have great potential to acquire hypoxic imaging with high sensitivity and more accuracy. We propose a novel
imaging strategy,which combined the
hybrid fluorescence molecular tomography-computed tomography (FMT-CT) and the
multispectral optoacoustic tomography (MSOT), for achieving three-dimensional (3D) quantitative evaluation
of NPC hypoxia in small animal models.The results could
not only detect the hypoxia in small sizes of NPCs and lymph nodes metatasis, but also visualize the
heterogeneity of hypoxia in 3D.
