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Abstract #3049

New class of biodegradable responsive phosphorus–containing contrast agent for 1H/31P MR

Natalia Ziółkowska1,2, Martin Hrubý3, Martin Vít1,4, Zdislava Pechrová3,5, and Daniel Jirák1,2
1Department of Computed Tomography, Magnetic Resonance and Clinical Experimental Spectroscopy, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 2First Faculty of Medicine, Institute of Biophysics and Informatics, Charles University, Prague, Czech Republic, 3Supramolecular polymer systems department, Institute of Macromolecular Chemistry, Prague, Czech Republic, 4Faculty of Mechatronics Informatics and Interdisciplinary Studies, Technical University of Liberec, Liberec, Czech Republic, 5Faculty of Sciences, Department of Physical and Macromolecular Chemistry, Charles University, Prague, Czech Republic

We present a new class of biodegradable responsive 31P phosphorus–containing contrast agent for dual 1H/31P MRI. Both 1H and 31P MR imaging modalities offer complementary information and can be easily combined at the same experiment. The switch to phosphorus MR signal can reflect biochemical changes in the organism. An implementation for 1H/31P MR at 4.7 T is presented and its properties are investigated.

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