Abstract #3036

Development of Computational Methods for B1-Corrected Hyperpolarized 13C MRI Human Studies

Philip M Lee¹, Hsin-Yu Chen², Jeremy W Gordon², Peder EZ Larson², Mark Van Criekinge², Michael A Ohliger², Duan Xu², John Kurhanewicz², Robert A Bok², Rahul Aggarwal³, Pamela N Munster³, and Daniel B Vigneron²

¹Department of Radiology & Biomedical Imaging, University of California, San Francisco, Berkeley, CA, United States, ²Department of Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ³Department of Medicine, University of California, San Francisco, San Francisco, CA, United States

The inhomogeneous B₁ excitation profile of ¹³C surface transmit/receive coils results in a decreasing gradient of flip angles for voxels increasingly farther away from the coil. For accurately quantifying the pyruvate to lactate conversion rate (k_PL), the flip angle needs to be corrected based on the B₁ excitation profile. A voxel-wise B₁ excitation field correction method for hyperpolarized ¹³C MRSI scans of human patients was developed and applied, yielding an improved quantitative accuracy of k_PL values in metastatic cancer patients. The corrected k_PL estimations agree with simulations where over-flip leads to an underestimation of k_PL, whereas under-flip leads to overestimation.

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