Abstract #3034

Hyperpolarized 13C MR imaging of metastatic prostate cancer murine models

Shubhangi Agarwal¹, Jinny Sun¹, Robert A Bok¹, Romelyn Delos Santos¹, Mark van Criekinge¹, Rahul Aggarwal², Daniel B Vigneron¹, John Kurhanewicz¹, and Renuka Sriram¹

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²2Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA, United States

The study of prostate patient derived xenografts in kidney, bone and liver demonstrated the impact of microenvironment on metabolic characteristics of the metastatic prostate cancer and how it differs with respect to the host organ’s characteristics. Hyperpolarized ¹³C MRI was able to identify the modifications in the pyruvate metabolism between the kidney, bone and liver tumors before and after therapeutic intervention. This study demonstrates that Hyperpolarized ¹³C MRI can be used to monitor the real time changes in metabolic profile of prostate cancer and its metastases.

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