The purpose of this study is to detect physiologic and metabolic changes in tumor-bearing mouse model in response to immune checkpoint blockade therapy by using multi-modal imaging methods including hyperpolarized 13C-MRI with [1-13C] pyruvate, with [1,4-13C2] fumarate, and DCE-MRI. Lactate/Pyruvate ratio tended to decrease in αPD-L1 Ab + αCTLA-4 Ab treated tumor in mouse model although not statistically significant. Significantly increased Malate/Fumarate ratio and higher permeability were observed in treated tumor. We will investigate capability of detecting early response to immune checkpoint blockade therapy using multi-modal imaging.
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