In this work, we investigated the influence of a fed versus fasted state on human heart metabolism using hyperpolarized [1-13C]pyruvate MRI in order to develop protocols for human studies of heart disease. Good image quality was obtained in all volunteers, and approximately 40-50% increases in the lactate and bicarbonate signals were observed in the fed state. Distinct metabolic patterns are observed between the left and right ventricle and warrant further investigation.
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