Abstract #2987

Towards structure and metabolism of glycogen C1-C6 by 13C MRS at 7T using broadband 1H decoupling and low-power NOE by means of bi-level WALTZ cycles

Eulalia Serés Roig¹ and Rolf Gruetter^1,2,3

¹Laboratory of Functional and Metabolic Imaging (LIFMET) - Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ²Centre d'Imagerie BioMédicale - Animal and Imaging Technology (CIBM-AIT) - Ecole Polytechnique de Lausanne (EPFL), Lausanne, Switzerland, ³Department of Radiology, Universities of Lausanne (UNIL) and Geneva (UNIGE), Lausanne, Switzerland

Glycogen metabolism is essential for glucose homeostasis in humans and may be disrupted in a variety of diseases. Largely neglected due to its low concentration, yet brain glycogen plays an active role in brain energy metabolism, such as during hypo-glycemia. Carbon-13 Magnetic Resonance Spectroscopy (¹³C MRS) allows the non-invasive detection of glycogen in vivo, while is typically done via the C₁ carbon signal. In this study, we explore the potential of ¹³C MRS at 7T using uniform ¹³C excitation and bi-level broadband ¹H-decoupling towards simultaneous detection of glycogen C₁-C₆ in vivo in human muscle, as a step towards brain studies.

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