Abstract #2982

Quantitative Human Cardiac 39K MRI at 7T: What is feasible?

Johanna Lott^1,2, Tanja Platt¹, Sebastian C Niesporek¹, Daniel Wenz³, Peter Bachert^1,2, Mark E Ladd^1,2,4, Thoralf Niendorf^5,6, and Armin M Nagel^1,7,8

¹Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Faculty of Physics and Astronomy, University of Heidelberg, Heidelberg, Germany, ³Center for Biomedical Imaging - Animal Imaging and Technology (CIBM-AIT), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁴Faculty of Medicine, University of Heidelberg, Heidelberg, Germany, ⁵Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, ⁶MRI. TOOLS GmbH, Berlin, Germany, ⁷Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, ⁸Institute of Medical Physics, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany

Monitoring the viability of myocardial tissue is of prognostic value after an ischemic event^1-3. Ultrahigh fields (B₀≥7T) facilitates cardiac ³⁹K MRI. However, short relaxation times, low signal-to-noise ratio, and low spatial resolution render the quantitative determination of the myocardial tissue potassium concentration (mTPC) challenging. We analyze the feasibility of quantitative cardiac ³⁹K MRI at 7T with simulations. For realistic noise conditions the mTPC can be determined with a deviation of 14% from the ground truth by applying a partial volume correction. Quantitative cardiac ³⁹K MRI would further benefit e.g. from higher magnetic field strengths (B₀>7T) or iterative reconstruction techniques.

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