Abstract #2974

Fast 31P-MRSI of the brain at 3T using concentric ring (CONCEPT) MRSI

William T Clarke¹, Lukas Hingerl², Wolfgang Bogner², Christopher T Rodgers^3,4, and Ladislav Valkovic^4,5

¹Wellcome Centre for Integrative Neuroimaging, NDCN, University of Oxford, Oxford, United Kingdom, ²High-field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ³Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom, ⁴Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, ⁵Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia

A density-weighted concentric ring trajectory MRSI sequence is created for ³¹P-MRSI of the human brain at 3T. The sequence is assessed in three subjects at five different acquisition times (7:28 – 1:07 minutes) and compared against resolution and time-matched 3D cartesian CSI sequences. The proposed CONCEPT MRSI sequences robustly measure 3D localised PCr/ATP ratios of the human brain 1.5 times faster than the minimum possible with CSI at a matched repetition time. This opens the possibility of fast dynamic measurements of PCr/ATP in whole human cerebrum at 3T.

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