This was a parallel investigation of esophageal tumor tissues and adjacent normal mucosal tissues alongside patient-matched serum samples by nuclear magnetic resonance (NMR)-based metabolomics, to investigate how serum metabolic phenotypes were linked to the changes in the biochemical landscape of esophageal tumors. These associations provide evidence of distinct metabolic signatures and pathway disturbances between tumor tissues and serum of esophageal cancer patients, and changes in serum metabolic signature could reflect reprogramming of the aforementioned metabolic pathways in EC tissues.
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