Abstract #2950

GSH and GABA decreases in IDH1 mutated low-grade gliomas detected by HERMES spectral editing at 3 T in vivo

Tao Gong¹, Richard Edden^2,3, and Guangbin Wang¹

¹Shandong Medical Imaging Research Institute, Jinan, China, ²Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

IDH1 mutation could result in better prognosis compared with wild-type, but the mechanisms remain largely unknown. GABA and GSH are low-concentration metabolites, could not be detected using conventional MRS, but playing an important role in energy production of glioma. HERMES can be thought of as two MEGA-PRESS experiments with the benefit of saving half the acquisition time to simultaneously detect GABA and GSH. The results demonstrated that HERMES is a reliable tool for the simultaneous detection of GABA and GSH signals, and both of them decreased significantly in IDH1 mutated low-grade gliomas.

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