Abstract #2937

Detection of metabolic alterations in the thalamus of the TMEV mouse model of multiple sclerosis at 9.4 Tesla

Poonam Choudhary^1,2, Suyog Pol², Marilena Preda^2,3, Robert Zivadinov^2,3, and Ferdinand Schweser^2,3

¹Department of Medical Physics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ²Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ³Center for Biomedical Imaging at the Clinical and Translational Science Institute, University at Buffalo, The State University of New York, Buffalo, NY, United States

This study aimed to characterize the metabolic alterations in the thalamus throughout the disease course of Theiler's murine encephalomyelitis virus (TMEV) in mice using 9.4T MRS, and relate the findings to the known effects of microglia activation on neurotransmitter homeostasis. Our study confirmed that TMEV models metabolite alterations in Multiple Sclerosis. Dynamics of neurotransmitter imbalance suggest that early thalamic dyshomeostatis is driven by neuronal loss in basal ganglia input.

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