Abstract #2925

Ultrashort-TE Liver 1H MR Spectroscopy in Alcohol Use Disorder at 3 T

Martin Gajdosik¹, Jonathan Wai^2,3, Karl Landheer¹, Diana Martinez^2,4, and Christoph Juchem^1,5

¹Department of Biomedical Engineering, Columbia University, New York City, NY, United States, ²Department of Psychiatry, Columbia University Irving Medical Center, New York City, NY, United States, ³New York State Psychiatric Institute, New York City, NY, United States, ⁴Department of Psychiatry, New York State Psychiatric Institute, New York City, NY, United States, ⁵Department of Radiology, Columbia University College of Physicians and Surgeons, New York City, NY, United States

Accurate detection of hepatocellular lipid content (HLC) in individuals with alcohol use disorder (AUD) is needed for early diagnosis of hepatic steatosis, a harbinger of serious liver diseases such as cirrhosis. Using a standard clinical 3T system and ultrashort-TE liver MRS, the proposed sequence employed asymmetric RF pulses with spoiler gradient cycling to achieve minimal TE of 5ms and minimal T₂ errors for reliable signal quantification. No difference was found in HCL and choline levels between controls and AUD subjects. After a 3-week abstinence period, changes in hepatic fat and choline levels were observed in subjects with AUD.

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